Plaque Calcification

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Coronary Calcification and Plaque Vulnerability: An Optical Coherence Tomographic Study.

BACKGROUND Spotty superficial calcium deposits have been implicated in plaque vulnerability based on previous intravascular imaging studies. Biomechanical models suggest that microcalcifications between 5 and 65 µm in diameter can intensify fibrous cap stress, promoting plaque rupture. However, the 100- to 200-µm resolution of intravascular ultrasound limits its ability to discriminate single c...

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Expression of NPP1 is regulated during atheromatous plaque calcification

Mutations of the ENPP1 gene encoding ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) are associated with medial calcification in infancy. While the inhibitory role of matrix proteins such as osteopontin (OPN) with respect to atherosclerotic plaque calcification has been established, the role of NPP1 in plaque calcification is not known. We assessed the degree of plaque calcification ...

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Calcification in original plaque and restenosis following carotid artery stenting

Background The relationship between calcification in primary plaque and recurrent stenosis after carotid artery stenting (CAS) is not established, but an inverse association with restenosis following carotid endarterectomy (CEA) has been suggested. Methods We retrospectively analyzed 75 plaques of 109 consecutive CAS with regard to calcification, using the calcium score and shape, location, a...

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Association Between Carotid Atherosclerotic Plaque Calcification and Intraplaque Hemorrhage

Vulnerable atherosclerotic plaque in carotid arteries is a major cause of cerebrovascular events, such as transient ischemia attack and ischemic stroke. Previous studies have shown that compositional characteristics, particularly intraplaque hemorrhage (IPH) and lipid-rich necrotic core, in carotid artery plaques play a key role in plaque vulnerability. In particular, it is increasingly evidenc...

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Direct imaging and quantification of carotid plaque calcification.

Carotid plaque calcification normally appears as a signal void with clinical MR sequences. Here, we describe the use of an adiabatic inversion recovery prepared two-dimensional ultrashort echo time sequence to image and characterize carotid plaque calcification using a clinical 3-T scanner. T(1), T 2*, and free water content were measured for seven carotid samples, and the results were compared...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2019

ISSN: 1079-5642,1524-4636

DOI: 10.1161/atvbaha.119.311574